Cell Senescence Entries for GDF15

Cell Types
Aortic endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced, Stress-induced
Senescence Effect
Induces
Primary Reference
Park et al. (2016) GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells. Oncotarget 7(9)9634-44 (PubMed)

GDF15 Gene Information

HGNC symbol
GDF15 
Aliases
MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB 
Common name
growth differentiation factor 15 
Entrez Id
9518
Description
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016].

GDF15 Ontologies

Gene Ontology
Process: GO:35860; glial cell-derived neurotrophic factor receptor signaling pathway
GO:51897; positive regulation of protein kinase B signaling
GO:30509; BMP signaling pathway
GO:43410; positive regulation of MAPK cascade
GO:60395; SMAD protein signal transduction
GO:7165; signal transduction
GO:7267; cell-cell signaling
GO:10862; positive regulation of pathway-restricted SMAD protein phosphorylation
GO:60400; negative regulation of growth hormone receptor signaling pathway
GO:7179; transforming growth factor beta receptor signaling pathway
GO:40015; negative regulation of multicellular organism growth
And 3 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5794; Golgi apparatus
GO:5576; extracellular region
GO:5615; extracellular space
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
Function: GO:8083; growth factor activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:5125; cytokine activity
GO:70700; BMP receptor binding
Show all GO terms

Homologs of GDF15 in Model Organisms

Mus musculus
Gdf15
Rattus norvegicus
Gdf15

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Gdf15
CellAge gene expression
  • This gene is present as GDF15

External links

OMIM
605312
Ensembl
ENSG00000130513
Entrez Gene
9518
UniGene
616962
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GDF15
GeneCards
GDF15