Cell Senescence Entries for HAS1

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Liu et al. (2020) A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. Aging (Albany NY) 11(12)4011-4031 (PubMed)

HAS1 Gene Information

HGNC symbol
HAS1 
Aliases
HAS 
Common name
hyaluronan synthase 1 
Entrez Id
3036
Description
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

HAS1 Ontologies

Gene Ontology
Process: GO:30213; hyaluronan biosynthetic process
GO:7155; cell adhesion
GO:45226; extracellular polysaccharide biosynthetic process
GO:85029; extracellular matrix assembly
GO:10764; negative regulation of fibroblast migration
GO:36120; cellular response to platelet-derived growth factor stimulus
GO:6024; glycosaminoglycan biosynthetic process
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
GO:5737; cytoplasm
Function: GO:50501; hyaluronan synthase activity
GO:16740; transferase activity
GO:16757; glycosyltransferase activity
GO:5515; protein binding
GO:42802; identical protein binding
Show all GO terms

Homologs of HAS1 in Model Organisms

Danio rerio
has1
Mus musculus
Has1
Rattus norvegicus
Has1

External links

OMIM
601463
Ensembl
ENSG00000105509
Entrez Gene
3036
UniGene
57697
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HAS1
GeneCards
HAS1