The HEPACAM gene and its putative association with human ageing

Cell Senescence Entries for HEPACAM

Cell Types: Breast cancer
Cell Lines: MCF-7
Cancer Cell?: Yes
Method: Overexpression
Type of senescence: Unclear
Senescence Effect: Induces
Primary Reference: Moh et al. (2009) Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells. Carcinogenesis 29(12)2298-305 (PubMed)

HGNC symbol: HEPACAM
Aliases: FLJ25530; GLIALCAM
Common name: hepatic and glial cell adhesion molecule
Entrez Id: 220296
Description: The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011].

Gene Ontology

Process:

GO:7049; cell cycle
GO:7155; cell adhesion
GO:40008; regulation of growth
GO:34613; cellular protein localization

Cellular component:

GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5911; cell-cell junction
GO:30424; axon

Function:

Show all GO terms