Cell Senescence Entries for HIF1A

Cell Types
Endometrial adenocarcinoma, Neuroblastoma
Cell Lines
HHUA, HWCA, Ishikawa, SK-N-BE(2)-C
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Cimmino et al. (2016) Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells. Sci Rep 5(2)11158 (PubMed)

HIF1A Gene Information

HGNC symbol
HIF1A 
Aliases
bHLHe78; HIF-1alpha; HIF1; MOP1; PASD8 
Common name
hypoxia inducible factor 1 subunit alpha 
Entrez Id
3091
Description
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011].

HIF1A Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:33554; cellular response to stress
GO:10468; regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:98586; cellular response to virus
GO:1666; response to hypoxia
GO:1525; angiogenesis
GO:1568; blood vessel development
And 83 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5829; cytosol
GO:1904115; axon cytoplasm
GO:16604; nuclear body
GO:785; chromatin
GO:31514; motile cilium
GO:32991; protein-containing complex
GO:5667; transcription regulator complex
And 2 more GO terms
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:31625; ubiquitin protein ligase binding
GO:3700; DNA-binding transcription factor activity
GO:19899; enzyme binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:19901; protein kinase binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
And 12 more GO terms
Show all GO terms

Homologs of HIF1A in Model Organisms

Danio rerio
hif1ab
Mus musculus
Hif1a
Rattus norvegicus
Hif1a

In other databases

GenAge human genes
  • This gene is present as HIF1A
LongevityMap
  • This gene is present as HIF1A

External links

OMIM
603348
Ensembl
ENSG00000100644
Entrez Gene
3091
UniGene
719495
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HIF1A
GeneCards
HIF1A