Cell Senescence Entries for HIPK2

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Donninger et al. (2015) NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2. J Cell Biol 208(6)777-89 (PubMed)

HIPK2 Gene Information

HGNC symbol
HIPK2 
Aliases
 
Common name
homeodomain interacting protein kinase 2 
Entrez Id
28996
Description
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

HIPK2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:18108; peptidyl-tyrosine phosphorylation
GO:6974; cellular response to DNA damage stimulus
GO:51726; regulation of cell cycle
GO:30218; erythrocyte differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1654; eye development
GO:18105; peptidyl-serine phosphorylation
GO:18107; peptidyl-threonine phosphorylation
And 33 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:16605; PML body
GO:90575; RNA polymerase II transcription regulator complex
GO:16604; nuclear body
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3713; transcription coactivator activity
GO:3714; transcription corepressor activity
And 5 more GO terms
Show all GO terms

Homologs of HIPK2 in Model Organisms

Danio rerio
hipk2
Mus musculus
Hipk2
Rattus norvegicus
Hipk2

In other databases

GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Hipk2

External links

OMIM
606868
Ensembl
ENSG00000064393
Entrez Gene
28996
UniGene
731417
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HIPK2
GeneCards
HIPK2