Cell Senescence Entries for HSP90AB1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
IMR-90, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Han et al. (2017) Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF. Cancer Res 77(2)343-354 (PubMed)

HSP90AB1 Gene Information

HGNC symbol
HSP90AB1 
Aliases
HSPC2; HSPCB 
Common name
heat shock protein 90 alpha family class B member 1 
Entrez Id
3326
Description
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012].

HSP90AB1 Ontologies

Gene Ontology
Process: GO:7004; telomere maintenance via telomerase
GO:6457; protein folding
GO:6986; response to unfolded protein
GO:51726; regulation of cell cycle
GO:1890; placenta development
GO:9410; response to xenobiotic stimulus
GO:9651; response to salt stress
GO:10033; response to organic substance
GO:21955; central nervous system neuron axonogenesis
GO:30010; establishment of cell polarity
GO:32092; positive regulation of protein binding
And 33 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5576; extracellular region
GO:42470; melanosome
GO:8180; COP9 signalosome
GO:5765; lysosomal membrane
And 19 more GO terms
Function: GO:70182; DNA polymerase binding
GO:3723; RNA binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:5515; protein binding
GO:16887; ATP hydrolysis activity
GO:46983; protein dimerization activity
GO:51082; unfolded protein binding
GO:2134; UTP binding
GO:2135; CTP binding
GO:5525; GTP binding
And 25 more GO terms
Show all GO terms

Homologs of HSP90AB1 in Model Organisms

Danio rerio
hsp90ab1
Drosophila melanogaster
Hsp83
Mus musculus
Hsp90ab1
Rattus norvegicus
Hsp90ab1

External links

OMIM
140572
Ensembl
ENSG00000096384
Entrez Gene
3326
UniGene
509736
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HSP90AB1
GeneCards
HSP90AB1