Cell Senescence Entries for IL1R1

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wajapeyee et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132(3)363-74 (PubMed)

IL1R1 Gene Information

HGNC symbol
IL1R1 
Aliases
CD121A; D2S1473; IL1R; IL1RA 
Common name
interleukin 1 receptor type 1 
Entrez Id
3554
Description
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013].

IL1R1 Ontologies

Gene Ontology
Process: GO:70498; interleukin-1-mediated signaling pathway
GO:7165; signal transduction
GO:19221; cytokine-mediated signaling pathway
GO:71345; cellular response to cytokine stimulus
GO:6954; inflammatory response
GO:6955; immune response
GO:32729; positive regulation of interferon-gamma production
GO:7166; cell surface receptor signaling pathway
GO:70555; response to interleukin-1
GO:50727; regulation of inflammatory response
GO:2000556; positive regulation of T-helper 1 cell cytokine production
And 3 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5576; extracellular region
GO:5887; integral component of plasma membrane
GO:9897; external side of plasma membrane
GO:9986; cell surface
Function: GO:4909; interleukin-1, type I, activating receptor activity
GO:16787; hydrolase activity
GO:3953; NAD+ nucleosidase activity
GO:4908; interleukin-1 receptor activity
GO:5515; protein binding
GO:50135; NAD(P)+ nucleosidase activity
GO:61809; NAD+ nucleotidase, cyclic ADP-ribose generating
GO:4888; transmembrane signaling receptor activity
GO:5161; platelet-derived growth factor receptor binding
GO:2020; protease binding
GO:19966; interleukin-1 binding
And 1 more GO terms
Show all GO terms

Homologs of IL1R1 in Model Organisms

Mus musculus
Il1r1
Rattus norvegicus
Il1r1

External links

OMIM
147810
Ensembl
ENSG00000115594
Entrez Gene
3554
UniGene
701982
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IL1R1
GeneCards
IL1R1