Cell Senescence Entries for ILF3

Cell Types
Fibroblast, Lung fibroblast
Cell Lines
IDH4, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Tominaga-Yamanaka et al. (2013) NF90 coordinately represses the senescence-associated secretory phenotype. Aging (Albany NY) 4(10)695-708 (PubMed)

ILF3 Gene Information

HGNC symbol
ILF3 
Aliases
DRBP76; MPHOSPH4; MPP4; MPP4110; NF110; NF110b; NF90; NF90a; NF90c; NF90ctv; NFAR-1; NFAR-2; NFAR110; NFAR90; TCP110 
Common name
interleukin enhancer binding factor 3 
Entrez Id
3609
Description
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014].

ILF3 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:17148; negative regulation of translation
GO:45893; positive regulation of transcription, DNA-templated
GO:51607; defense response to virus
GO:6468; protein phosphorylation
GO:45071; negative regulation of viral genome replication
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5739; mitochondrion
GO:1990904; ribonucleoprotein complex
GO:5576; extracellular region
GO:43231; intracellular membrane-bounded organelle
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:3725; double-stranded RNA binding
GO:3677; DNA binding
GO:3727; single-stranded RNA binding
GO:35925; mRNA 3'-UTR AU-rich region binding
Show all GO terms

Homologs of ILF3 in Model Organisms

Danio rerio
ilf3
Mus musculus
Ilf3
Rattus norvegicus
Ilf3

In other databases

CellAge gene expression
  • This gene is present as ILF3

External links

OMIM
603182
Ensembl
ENSG00000129351
Entrez Gene
3609
UniGene
465885
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ILF3
GeneCards
ILF3