Cell Senescence Entries for IRAK4

Cell Types
Breast cancer, Melanoma, Prostate cancer
Cell Lines
M628, MCF-7, PC-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Ye et al. (2015) TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence. EMBO Mol Med 6(10)1294-311 (PubMed)

IRAK4 Gene Information

HGNC symbol
IRAK4 
Aliases
NY-REN-64 
Common name
interleukin 1 receptor associated kinase 4 
Entrez Id
51135
Description
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

IRAK4 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:7165; signal transduction
GO:2376; immune system process
GO:45087; innate immune response
GO:2224; toll-like receptor signaling pathway
GO:35556; intracellular signal transduction
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:19221; cytokine-mediated signaling pathway
GO:70498; interleukin-1-mediated signaling pathway
GO:2755; MyD88-dependent toll-like receptor signaling pathway
And 6 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5886; plasma membrane
GO:5829; cytosol
GO:10008; endosome membrane
GO:5615; extracellular space
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:287; magnesium ion binding
GO:5515; protein binding
GO:19901; protein kinase binding
And 2 more GO terms
Show all GO terms

Homologs of IRAK4 in Model Organisms

Caenorhabditis elegans
pik-1
Danio rerio
irak4
Mus musculus
Irak4
Rattus norvegicus
Irak4

External links

OMIM
606883
Ensembl
ENSG00000198001
Entrez Gene
51135
UniGene
138499
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IRAK4
GeneCards
IRAK4