Cell Senescence Entries for ITGB4

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Liu et al. (2008) Vascular endothelial cell senescence mediated by integrin beta4 in vitro. FEBS Lett 581(28)5337-42 (PubMed)

ITGB4 Gene Information

HGNC symbol
ITGB4 
Aliases
CD104 
Common name
integrin subunit beta 4 
Entrez Id
3691
Description
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

ITGB4 Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:6914; autophagy
GO:7229; integrin-mediated signaling pathway
GO:7154; cell communication
GO:7160; cell-matrix adhesion
GO:31581; hemidesmosome assembly
GO:48870; cell motility
GO:16477; cell migration
GO:33627; cell adhesion mediated by integrin
GO:9611; response to wounding
GO:43589; skin morphogenesis
And 7 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5730; nucleolus
GO:5886; plasma membrane
GO:31965; nuclear membrane
GO:30054; cell junction
GO:9986; cell surface
GO:8305; integrin complex
GO:31252; cell leading edge
GO:70062; extracellular exosome
GO:5925; focal adhesion
And 5 more GO terms
Function: GO:5515; protein binding
GO:5178; integrin binding
GO:1664; G protein-coupled receptor binding
GO:31994; insulin-like growth factor I binding
GO:38132; neuregulin binding
Show all GO terms

Homologs of ITGB4 in Model Organisms

Danio rerio
itgb4
Mus musculus
Itgb4
Rattus norvegicus
Itgb4

External links

OMIM
147557
Ensembl
ENSG00000132470
Entrez Gene
3691
UniGene
632226
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ITGB4
GeneCards
ITGB4