Cell Senescence Entries for ITPR2

Cell Types
Mammary epithelial
Cell Lines
HEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wiel et al. (2016) Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence. Nat Commun 5(2)3792 (PubMed)

ITPR2 Gene Information

HGNC symbol
ITPR2 
Aliases
CFAP48; IP3R2 
Common name
inositol 1,4,5-trisphosphate receptor type 2 
Entrez Id
3709
Description
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015].

ITPR2 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:6811; ion transport
GO:6816; calcium ion transport
GO:70588; calcium ion transmembrane transport
GO:48016; inositol phosphate-mediated signaling
GO:7165; signal transduction
GO:51209; release of sequestered calcium ion into cytosol
GO:1666; response to hypoxia
GO:71320; cellular response to cAMP
GO:71361; cellular response to ethanol
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:16529; sarcoplasmic reticulum
GO:31095; platelet dense tubular network membrane
GO:33017; sarcoplasmic reticulum membrane
GO:43235; receptor complex
GO:30667; secretory granule membrane
And 4 more GO terms
Function: GO:5216; ion channel activity
GO:5262; calcium channel activity
GO:70679; inositol 1,4,5 trisphosphate binding
GO:5509; calcium ion binding
GO:5220; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:35091; phosphatidylinositol binding
GO:97110; scaffold protein binding
GO:44325; transmembrane transporter binding
GO:15085; calcium ion transmembrane transporter activity
GO:15278; calcium-release channel activity
Show all GO terms

Homologs of ITPR2 in Model Organisms

Mus musculus
Itpr2
Rattus norvegicus
Itpr2

External links

OMIM
600144
Ensembl
ENSG00000123104
Entrez Gene
3709
UniGene
512235
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ITPR2
GeneCards
ITPR2