Cell Senescence Entries for ITPR3

Cell Types
Mammary epithelial
Cell Lines
HEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wiel et al. (2016) Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence. Nat Commun 5(2)3792 (PubMed)

ITPR3 Gene Information

HGNC symbol
ITPR3 
Aliases
IP3R3 
Common name
inositol 1,4,5-trisphosphate receptor type 3 
Entrez Id
3710
Description
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010].

ITPR3 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:6811; ion transport
GO:6816; calcium ion transport
GO:70588; calcium ion transmembrane transport
GO:48016; inositol phosphate-mediated signaling
GO:7204; positive regulation of cytosolic calcium ion concentration
GO:51209; release of sequestered calcium ion into cytosol
GO:7186; G protein-coupled receptor signaling pathway
GO:51592; response to calcium ion
GO:60402; calcium ion transport into cytosol
GO:50909; sensory perception of taste
And 6 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5886; plasma membrane
GO:16529; sarcoplasmic reticulum
GO:31095; platelet dense tubular network membrane
GO:43235; receptor complex
GO:5887; integral component of plasma membrane
GO:43025; neuronal cell body
And 10 more GO terms
Function: GO:5515; protein binding
GO:5216; ion channel activity
GO:5262; calcium channel activity
GO:70679; inositol 1,4,5 trisphosphate binding
GO:5509; calcium ion binding
GO:5220; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:35091; phosphatidylinositol binding
GO:15278; calcium-release channel activity
GO:822; inositol hexakisphosphate binding
GO:43533; inositol 1,3,4,5 tetrakisphosphate binding
Show all GO terms

Homologs of ITPR3 in Model Organisms

Caenorhabditis elegans
itr-1
Danio rerio
itpr3
Drosophila melanogaster
Itp-r83A
Mus musculus
Itpr3
Rattus norvegicus
Itpr3

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as itr-1

External links

OMIM
147267
Ensembl
ENSG00000096433
Entrez Gene
3710
UniGene
65758
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ITPR3
GeneCards
ITPR3