Cell Senescence Entries for ITSN2

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
HS68, WI-38
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Rajarajacholan et al. (2013) The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. PLoS Biol 11(3)e1001502 (PubMed)

ITSN2 Gene Information

HGNC symbol
ITSN2 
Aliases
KIAA1256; PRO2015; SH3D1B; SH3P18; SWA; SWAP 
Common name
intersectin 2 
Entrez Id
50618
Description
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017].

ITSN2 Ontologies

Gene Ontology
Process: GO:50790; regulation of catalytic activity
GO:30154; cell differentiation
GO:6897; endocytosis
GO:16197; endosomal transport
GO:1903861; positive regulation of dendrite extension
GO:150007; clathrin-dependent synaptic vesicle endocytosis
Cellular component: GO:5737; cytoplasm
GO:98793; presynapse
GO:5829; cytosol
GO:70062; extracellular exosome
GO:5905; clathrin-coated pit
GO:5813; centrosome
Function: GO:46872; metal ion binding
GO:5509; calcium ion binding
GO:5085; guanyl-nucleotide exchange factor activity
GO:5515; protein binding
GO:60090; molecular adaptor activity
Show all GO terms

Homologs of ITSN2 in Model Organisms

Caenorhabditis elegans
itsn-1
Drosophila melanogaster
Dap160
Mus musculus
Itsn2
Rattus norvegicus
Itsn2

External links

OMIM
604464
Ensembl
ENSG00000198399
Entrez Gene
50618
UniGene
432562
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ITSN2
GeneCards
ITSN2