Cell Senescence Entries for JAK2
- Cell Types
- Melanocyte
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Wang et al. (2015) Interferon-γ induces senescence in normal human melanocytes. PLoS One 9(3)e93232 (PubMed)
JAK2 Gene Information
- HGNC symbol
- JAK2
- Aliases
- JTK10
- Common name
- Janus kinase 2
- Entrez Id
- 3717
- Description
- This gene encodes a non-receptor tyrosine kinase that plays a central role in cytokine and growth factor signalling. The primary isoform of this protein has an N-terminal FERM domain that is required for erythropoietin receptor association, an SH2 domain that binds STAT transcription factors, a pseudokinase domain and a C-terminal tyrosine kinase domain. Cytokine binding induces autophosphorylation and activation of this kinase. This kinase then recruits and phosphorylates signal transducer and activator of transcription (STAT) proteins. Growth factors like TGF-beta 1 also induce phosphorylation and activation of this kinase and translocation of downstream STAT proteins to the nucleus where they influence gene transcription. Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced by B cells, T cells, dendritic cells and macrophages to produce an immune response or inflammation. Disregulation of the IL6/JAK2/STAT3 signalling pathways produces increased cellular proliferation and myeloproliferative neoplasms of hematopoietic stem cells. A nonsynonymous mutation in the pseudokinase domain of this gene disrupts the domains inhibitory effect and results in constitutive tyrosine phosphorylation activity and hypersensitivity to cytokine signalling. This gene and the IL6/JAK2/STAT3 signalling pathway is a therapeutic target for the treatment of excessive inflammatory responses to viral infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020].
JAK2 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:35556; intracellular signal transduction
GO:18108; peptidyl-tyrosine phosphorylation
GO:6325; chromatin organization
GO:19221; cytokine-mediated signaling pathway
GO:7165; signal transduction
GO:2376; immune system process
GO:45087; innate immune response
GO:2250; adaptive immune response
GO:46777; protein autophosphorylation
And 102 more GO terms Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5925; focal adhesion
GO:12505; endomembrane system
GO:5856; cytoskeleton
GO:5634; nucleus
GO:5829; cytosol
GO:31904; endosome lumen
GO:30526; granulocyte macrophage colony-stimulating factor receptor complex
And 9 more GO terms
Show all GO termsFunction: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4715; non-membrane spanning protein tyrosine kinase activity
GO:42393; histone binding
GO:46872; metal ion binding
GO:5515; protein binding
And 15 more GO terms
Homologs of JAK2 in Model Organisms
In other databases
External links
- OMIM
- 147796
- Ensembl
- ENSG00000096968
- Entrez Gene
- 3717
- UniGene
- 656213
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- JAK2
- GeneCards
- JAK2