Cell Senescence Entries for KCNA1

Cell Types
Mammary epithelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Lallet-Daher et al. (2014) Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Res 73(16)5253-65 (PubMed)

KCNA1 Gene Information

HGNC symbol
KCNA1 
Aliases
AEMK; HUK1; Kv1.1; MBK1; RBK1 
Common name
potassium voltage-gated channel subfamily A member 1 
Entrez Id
3736
Description
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008].

KCNA1 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:6811; ion transport
GO:6813; potassium ion transport
GO:34765; regulation of ion transmembrane transport
GO:51260; protein homooligomerization
GO:71805; potassium ion transmembrane transport
GO:99505; regulation of presynaptic membrane potential
GO:60078; regulation of postsynaptic membrane potential
GO:7268; chemical synaptic transmission
GO:42391; regulation of membrane potential
GO:50905; neuromuscular process
And 15 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:31410; cytoplasmic vesicle
GO:5783; endoplasmic reticulum
GO:5886; plasma membrane
GO:5829; cytosol
GO:30054; cell junction
GO:42995; cell projection
GO:8076; voltage-gated potassium channel complex
GO:30425; dendrite
GO:45202; synapse
And 18 more GO terms
Function: GO:5216; ion channel activity
GO:5244; voltage-gated ion channel activity
GO:5249; voltage-gated potassium channel activity
GO:5267; potassium channel activity
GO:5515; protein binding
GO:5251; delayed rectifier potassium channel activity
GO:97718; disordered domain specific binding
GO:15079; potassium ion transmembrane transporter activity
GO:99508; voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
GO:1905030; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
Show all GO terms

Homologs of KCNA1 in Model Organisms

Danio rerio
LOC571208
Mus musculus
Kcna1
Rattus norvegicus
Kcna1

External links

OMIM
176260
Ensembl
ENSG00000111262
Entrez Gene
3736
UniGene
416139
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KCNA1
GeneCards
KCNA1