Cell Senescence Entries for KDM1A

Cell Types
Fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Yu et al. (2018) Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell 33(2)322-336.e8 (PubMed)

KDM1A Gene Information

HGNC symbol
KDM1A 
Aliases
AOF2; BHC110; KDM1; KIAA0601; LSD1 
Common name
lysine demethylase 1A 
Entrez Id
23028
Description
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].

KDM1A Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:34720; histone H3-K4 demethylation
GO:6325; chromatin organization
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:33169; histone H3-K9 demethylation
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:45892; negative regulation of transcription, DNA-templated
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:120162; positive regulation of cold-induced thermogenesis
And 29 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:781; chromosome, telomeric region
GO:32991; protein-containing complex
GO:785; chromatin
GO:5667; transcription regulator complex
GO:1990391; DNA repair complex
Function: GO:5515; protein binding
GO:16491; oxidoreductase activity
GO:50660; flavin adenine dinucleotide binding
GO:32453; histone demethylase activity (H3-K4 specific)
GO:30374; nuclear receptor coactivator activity
GO:3682; chromatin binding
GO:32454; histone demethylase activity (H3-K9 specific)
GO:43426; MRF binding
GO:32452; histone demethylase activity
GO:19899; enzyme binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
And 7 more GO terms
Show all GO terms

Homologs of KDM1A in Model Organisms

Caenorhabditis elegans
lsd-1
Danio rerio
kdm1a
Drosophila melanogaster
Su(var)3-3
Mus musculus
Kdm1a
Rattus norvegicus
Kdm1a

In other databases

CellAge gene expression
  • This gene is present as KDM1A

External links

OMIM
609132
Ensembl
ENSG00000004487
Entrez Gene
23028
UniGene
591518
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KDM1A
GeneCards
KDM1A