Cell Senescence Entries for KDM4A

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Unclear
Primary Reference
Mallette et al. (2013) JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5. Cell Rep 2(5)1233-43 (PubMed)

KDM4A Gene Information

HGNC symbol
KDM4A 
Aliases
JHDM3A; JMJD2; JMJD2A; KIAA0677; TDRD14A 
Common name
lysine demethylase 4A 
Entrez Id
9682
Description
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009].

KDM4A Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6338; chromatin remodeling
GO:10507; negative regulation of autophagy
GO:33169; histone H3-K9 demethylation
GO:10629; negative regulation of gene expression
GO:10628; positive regulation of gene expression
GO:14898; cardiac muscle hypertrophy in response to stress
GO:16577; histone demethylation
GO:31667; response to nutrient levels
GO:45666; positive regulation of neuron differentiation
And 5 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:1650; fibrillar center
GO:5721; pericentric heterochromatin
GO:5737; cytoplasm
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:8270; zinc ion binding
GO:31625; ubiquitin protein ligase binding
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:35064; methylated histone binding
GO:32452; histone demethylase activity
GO:32454; histone demethylase activity (H3-K9 specific)
GO:51864; histone demethylase activity (H3-K36 specific)
Show all GO terms

Homologs of KDM4A in Model Organisms

Danio rerio
si:ch211-215f22.3
Mus musculus
Kdm4a
Rattus norvegicus
Kdm4a

External links

OMIM
609764
Ensembl
ENSG00000066135
Entrez Gene
9682
UniGene
155983
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KDM4A
GeneCards
KDM4A