Cell Senescence Entries for KDM4C

Cell Types
Fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Yu et al. (2018) Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell 33(2)322-336.e8 (PubMed)

KDM4C Gene Information

HGNC symbol
KDM4C 
Aliases
GASC1; JMJD2C; KIAA0780; TDRD14C 
Common name
lysine demethylase 4C 
Entrez Id
23081
Description
This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].

KDM4C Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:6338; chromatin remodeling
GO:8284; positive regulation of cell population proliferation
GO:33169; histone H3-K9 demethylation
GO:6357; regulation of transcription by RNA polymerase II
GO:60765; regulation of androgen receptor signaling pathway
GO:70544; histone H3-K36 demethylation
GO:1825; blastocyst formation
GO:10468; regulation of gene expression
GO:19827; stem cell population maintenance
GO:1900113; negative regulation of histone H3-K9 trimethylation
And 4 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:5721; pericentric heterochromatin
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:8270; zinc ion binding
GO:51213; dioxygenase activity
GO:32452; histone demethylase activity
GO:32454; histone demethylase activity (H3-K9 specific)
GO:19899; enzyme binding
GO:50681; androgen receptor binding
GO:51864; histone demethylase activity (H3-K36 specific)
Show all GO terms

Homologs of KDM4C in Model Organisms

Mus musculus
Kdm4c
Rattus norvegicus
Kdm4c

External links

OMIM
605469
Ensembl
ENSG00000107077
Entrez Gene
23081
UniGene
709425
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KDM4C
GeneCards
KDM4C