Cell Senescence Entries for KDM5B

Cell Types
Colon cancer
Cell Lines
COLO 201, DLD1, HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Ohta et al. (2013) Depletion of JARID1B induces cellular senescence in human colorectal cancer. Int J Oncol 42(4)1212-8 (PubMed)

KDM5B Gene Information

HGNC symbol
KDM5B 
Aliases
CT31; JARID1B; PLU-1; PPP1R98; RBBP2H1A 
Common name
lysine demethylase 5B 
Entrez Id
10765
Description
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].

KDM5B Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:48511; rhythmic process
GO:6338; chromatin remodeling
GO:34721; histone H3-K4 demethylation, trimethyl-H3-K4-specific
GO:34720; histone H3-K4 demethylation
GO:45892; negative regulation of transcription, DNA-templated
GO:7338; single fertilization
GO:9791; post-embryonic development
GO:10628; positive regulation of gene expression
GO:33601; positive regulation of mammary gland epithelial cell proliferation
GO:44344; cellular response to fibroblast growth factor stimulus
And 9 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:8270; zinc ion binding
GO:3677; DNA binding
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:32452; histone demethylase activity
GO:34647; histone demethylase activity (H3-trimethyl-K4 specific)
GO:32453; histone demethylase activity (H3-K4 specific)
GO:42393; histone binding
GO:3714; transcription corepressor activity
And 2 more GO terms
Show all GO terms

Homologs of KDM5B in Model Organisms

Danio rerio
kdm5bb
Mus musculus
Kdm5b
Rattus norvegicus
Kdm5b
Saccharomyces cerevisiae
ECM5

External links

OMIM
605393
Ensembl
ENSG00000117139
Entrez Gene
10765
UniGene
443650
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KDM5B
GeneCards
KDM5B