Cell Senescence Entries for KLF4

Cell Types
Colon cancer, Stomach cancer
Cell Lines
AGS, SW480
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Xu et al. (2018) Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway. Oncotarget 7(37)60290-60302 (PubMed)

KLF4 Gene Information

HGNC symbol
KLF4 
Aliases
EZF; GKLF 
Common name
Kruppel like factor 4 
Entrez Id
9314
Description
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].

KLF4 Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:45892; negative regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45595; regulation of cell differentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:8285; negative regulation of cell population proliferation
GO:51973; positive regulation of telomerase activity
GO:10629; negative regulation of gene expression
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
And 40 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:15630; microtubule cytoskeleton
GO:785; chromatin
GO:791; euchromatin
GO:5667; transcription regulator complex
GO:5737; cytoplasm
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:8270; zinc ion binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
And 6 more GO terms
Show all GO terms

Homologs of KLF4 in Model Organisms

Danio rerio
klf4b
Drosophila melanogaster
cbt
Mus musculus
Klf4
Rattus norvegicus
Klf4

External links

OMIM
602253
Ensembl
ENSG00000136826
Entrez Gene
9314
UniGene
376206
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KLF4
GeneCards
KLF4