Cell Senescence Entries for LATS1

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

LATS1 Gene Information

HGNC symbol
LATS1 
Aliases
WARTS 
Common name
large tumor suppressor kinase 1 
Entrez Id
9113
Description
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017].

LATS1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:35329; hippo signaling
GO:51301; cell division
GO:278; mitotic cell cycle
GO:35556; intracellular signal transduction
GO:9755; hormone-mediated signaling pathway
GO:18105; peptidyl-serine phosphorylation
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:43065; positive regulation of apoptotic process
And 19 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5815; microtubule organizing center
GO:5819; spindle
GO:30496; midbody
GO:922; spindle pole
GO:5829; cytosol
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:287; magnesium ion binding
And 3 more GO terms
Show all GO terms

Homologs of LATS1 in Model Organisms

Danio rerio
lats1
Mus musculus
Lats1
Rattus norvegicus
Lats1
Schizosaccharomyces pombe
mkh1

External links

OMIM
603473
Ensembl
ENSG00000131023
Entrez Gene
9113
UniGene
549084
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LATS1
GeneCards
LATS1