Cell Senescence Entries for LMNB1
- Cell Types
- Lung fibroblast
- Cell Lines
- WI-38
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Shimi et al. (2012) The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev 25(24)2579-93 (PubMed)
LMNB1 Gene Information
- HGNC symbol
- LMNB1
- Aliases
- Common name
- lamin B1
- Entrez Id
- 4001
- Description
- This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
LMNB1 Ontologies
- Gene Ontology
-
Process: GO:6998; nuclear envelope organization
Cellular component: GO:5882; intermediate filament
GO:5634; nucleus
GO:16020; membrane
GO:5635; nuclear envelope
GO:31965; nuclear membrane
GO:5637; nuclear inner membrane
GO:5654; nucleoplasm
GO:5652; nuclear lamina
GO:5638; lamin filament
GO:16363; nuclear matrix
Show all GO termsFunction: GO:5515; protein binding
GO:5198; structural molecule activity
GO:3690; double-stranded DNA binding
GO:43274; phospholipase binding
GO:1990837; sequence-specific double-stranded DNA binding
Homologs of LMNB1 in Model Organisms
In other databases
External links
- OMIM
- 150340
- Ensembl
- ENSG00000113368
- Entrez Gene
- 4001
- UniGene
- 89497
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- LMNB1
- GeneCards
- LMNB1