Cell Senescence Entries for MAEL

Cell Types
Foreskin fibroblast
Cell Lines
BJ-5ta
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2018) Mael is essential for cancer cell survival and tumorigenesis through protection of genetic integrity. Oncotarget 8(3)5026-5037 (PubMed)

MAEL Gene Information

HGNC symbol
MAEL 
Aliases
CT128; FLJ14904; SPATA35 
Common name
maelstrom spermatogenic transposon silencer 
Entrez Id
84944
Description

MAEL Ontologies

Gene Ontology
Process: GO:30154; cell differentiation
GO:31047; gene silencing by RNA
GO:51321; meiotic cell cycle
GO:7283; spermatogenesis
GO:45892; negative regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:902; cell morphogenesis
GO:6974; cellular response to DNA damage stimulus
GO:7129; homologous chromosome pairing at meiosis
GO:7140; male meiotic nuclear division
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
And 8 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:785; chromatin
GO:1741; XY body
GO:30849; autosome
GO:33391; chromatoid body
GO:43186; P granule
GO:48471; perinuclear region of cytoplasm
GO:71547; piP-body
Function: GO:3677; DNA binding
GO:43565; sequence-specific DNA binding
Show all GO terms

Homologs of MAEL in Model Organisms

Drosophila melanogaster
mael
Mus musculus
Mael
Rattus norvegicus
Mael

External links

OMIM
611368
Ensembl
ENSG00000143194
Entrez Gene
84944
UniGene
651245
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAEL
GeneCards
MAEL