Cell Senescence Entries for MAP3K14

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown, Mutation
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Ho et al. (2012) HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA. J Virol 86(17)9474-83 (PubMed)

MAP3K14 Gene Information

HGNC symbol
MAP3K14 
Aliases
FTDCR1B; HS; HSNIK; NIK 
Common name
mitogen-activated protein kinase kinase kinase 14 
Entrez Id
9020
Description
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008].

MAP3K14 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:165; MAPK cascade
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:51607; defense response to virus
GO:6955; immune response
GO:71260; cellular response to mechanical stimulus
GO:7249; I-kappaB kinase/NF-kappaB signaling
GO:38061; NIK/NF-kappaB signaling
Cellular component: GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:1650; fibrillar center
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4709; MAP kinase kinase kinase activity
GO:4704; NF-kappaB-inducing kinase activity
And 1 more GO terms
Show all GO terms

Homologs of MAP3K14 in Model Organisms

Danio rerio
si:dkey-260c8.4
Mus musculus
Map3k14
Rattus norvegicus
Map3k14

External links

OMIM
604655
Ensembl
ENSG00000006062
Entrez Gene
9020
UniGene
668927
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAP3K14
GeneCards
MAP3K14