Cell Senescence Entries for MAP4K1

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

MAP4K1 Gene Information

HGNC symbol
MAP4K1 
Aliases
HPK1 
Common name
mitogen-activated protein kinase kinase kinase kinase 1 
Entrez Id
11184
Description

MAP4K1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:46777; protein autophosphorylation
GO:43410; positive regulation of MAPK cascade
GO:7254; JNK cascade
GO:8283; cell population proliferation
GO:1904628; cellular response to phorbol 13-acetate 12-myristate
GO:35556; intracellular signal transduction
GO:165; MAPK cascade
Cellular component: GO:16020; membrane
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:8349; MAP kinase kinase kinase kinase activity
Show all GO terms

Homologs of MAP4K1 in Model Organisms

Mus musculus
Map4k1
Rattus norvegicus
Map4k1

External links

OMIM
601983
Ensembl
ENSG00000104814
Entrez Gene
11184
UniGene
95424
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAP4K1
GeneCards
MAP4K1