Cell Senescence Entries for MDK

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Liu et al. (2020) A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. Aging (Albany NY) 11(12)4011-4031 (PubMed)

MDK Gene Information

HGNC symbol
MDK 
Aliases
FLJ27379; MK; NEGF2 
Common name
midkine 
Entrez Id
4192
Description
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012].

MDK Ontologies

Gene Ontology
Process: GO:30154; cell differentiation
GO:7399; nervous system development
GO:7010; cytoskeleton organization
GO:51781; positive regulation of cell division
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:2001224; positive regulation of neuron migration
GO:30335; positive regulation of cell migration
GO:50729; positive regulation of inflammatory response
GO:2000179; positive regulation of neural precursor cell proliferation
GO:48477; oogenesis
GO:43524; negative regulation of neuron apoptotic process
And 55 more GO terms
Cellular component: GO:5576; extracellular region
GO:62023; collagen-containing extracellular matrix
GO:5737; cytoplasm
GO:42995; cell projection
Function: GO:8083; growth factor activity
GO:5515; protein binding
GO:8201; heparin binding
GO:35374; chondroitin sulfate binding
GO:1904399; heparan sulfate binding
Show all GO terms

Homologs of MDK in Model Organisms

Danio rerio
mdkb
Mus musculus
Mdk
Rattus norvegicus
Mdk

In other databases

CellAge gene expression
  • This gene is present as MDK

External links

OMIM
162096
Ensembl
ENSG00000110492
Entrez Gene
4192
UniGene
82045
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MDK
GeneCards
MDK