Cell Senescence Entries for MED12

Cell Types
Lung cancer
Cell Lines
PC-9
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Xu et al. (2020) MED12 exerts an emerging role in actin-mediated cytokinesis via LIMK2/cofilin pathway in NSCLC. Mol Cancer 18(1)93 (PubMed)

MED12 Gene Information

HGNC symbol
MED12 
Aliases
ARC240; CAGH45; FGS1; HOPA; KIAA0192; Kto; OKS; OPA1; TNRC11; TRAP230 
Common name
mediator complex subunit 12 
Entrez Id
9968
Description
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009].

MED12 Ontologies

Gene Ontology
Process: GO:6357; regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:60261; positive regulation of transcription initiation from RNA polymerase II promoter
GO:1756; somitogenesis
GO:1843; neural tube closure
GO:7492; endoderm development
GO:7507; heart development
GO:14003; oligodendrocyte development
GO:14044; Schwann cell development
GO:16567; protein ubiquitination
And 11 more GO terms
Cellular component: GO:16592; mediator complex
GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:151; ubiquitin ligase complex
Function: GO:3712; transcription coregulator activity
GO:8013; beta-catenin binding
GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:30374; nuclear receptor coactivator activity
GO:19904; protein domain specific binding
GO:8022; protein C-terminus binding
GO:42809; vitamin D receptor binding
GO:46966; thyroid hormone receptor binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
And 2 more GO terms
Show all GO terms

Homologs of MED12 in Model Organisms

Danio rerio
med12
Drosophila melanogaster
kto
Mus musculus
Med12
Rattus norvegicus
Med12

External links

OMIM
300188
Ensembl
ENSG00000184634
Entrez Gene
9968
UniGene
409226
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MED12
GeneCards
MED12