Cell Senescence Entries for MEIS2

Cell Types
B lymphocyte
Cell Lines
SKO-007
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Abruzzese et al. (2020) The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors. Cell Death Dis 10(4)324 (PubMed)

MEIS2 Gene Information

HGNC symbol
MEIS2 
Aliases
HsT18361; MRG1 
Common name
Meis homeobox 2 
Entrez Id
4212
Description
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

MEIS2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:9887; animal organ morphogenesis
GO:9880; embryonic pattern specification
GO:1654; eye development
GO:7420; brain development
GO:8284; positive regulation of cell population proliferation
GO:45638; negative regulation of myeloid cell differentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:8542; visual learning
And 6 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:48471; perinuclear region of cytoplasm
GO:785; chromatin
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:8134; transcription factor binding
GO:43565; sequence-specific DNA binding
Show all GO terms

Homologs of MEIS2 in Model Organisms

Danio rerio
meis1
Mus musculus
Meis2
Rattus norvegicus
Meis2

External links

OMIM
601740
Ensembl
ENSG00000134138
Entrez Gene
4212
UniGene
510989
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MEIS2
GeneCards
MEIS2