Cell Senescence Entries for MIF

Cell Types
Mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Palumbo et al. (2014) Macrophage migration inhibitory factor regulates AKT signaling in hypoxic culture to modulate senescence of human mesenchymal stem cells. Stem Cells Dev 23(8)852-65 (PubMed)

MIF Gene Information

HGNC symbol
MIF 
Aliases
GIF; GLIF 
Common name
macrophage migration inhibitory factor 
Entrez Id
4282
Description
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008].

MIF Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:2376; immune system process
GO:45087; innate immune response
GO:6954; inflammatory response
GO:1516; prostaglandin biosynthetic process
GO:7166; cell surface receptor signaling pathway
GO:8284; positive regulation of cell population proliferation
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:32760; positive regulation of tumor necrosis factor production
GO:30336; negative regulation of cell migration
And 29 more GO terms
Cellular component: GO:5615; extracellular space
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5576; extracellular region
GO:31982; vesicle
GO:70062; extracellular exosome
GO:9986; cell surface
GO:5886; plasma membrane
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
And 1 more GO terms
Function: GO:5515; protein binding
GO:16853; isomerase activity
GO:5125; cytokine activity
GO:42802; identical protein binding
GO:50178; phenylpyruvate tautomerase activity
GO:42056; chemoattractant activity
GO:4167; dopachrome isomerase activity
GO:5126; cytokine receptor binding
GO:2020; protease binding
Show all GO terms

Homologs of MIF in Model Organisms

Caenorhabditis elegans
mif-1
Danio rerio
mif
Mus musculus
Mif
Rattus norvegicus
RGD1560513

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Mif
GenAge human genes
  • This gene is present as MIF

External links

OMIM
153620
Ensembl
ENSG00000276701
Entrez Gene
4282
UniGene
407995
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MIF
GeneCards
MIF