Cell Senescence Entries for MRTFA

Cell Types
Liver cancer
Cell Lines
HuH6, Huh7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Hampl et al. (2014) Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence. EMBO Mol Med 5(9)1367-82 (PubMed)

MRTFA Gene Information

HGNC symbol
MRTFA 
Aliases
BSAC; KIAA1438; MAL; MKL; MKL1; MRTF-A 
Common name
myocardin related transcription factor A 
Entrez Id
57591
Description
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

MRTFA Ontologies

Gene Ontology
Process: GO:45944; positive regulation of transcription by RNA polymerase II
GO:10735; positive regulation of transcription via serum response element binding
GO:30036; actin cytoskeleton organization
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:51145; smooth muscle cell differentiation
GO:44319; wound healing, spreading of cells
GO:6357; regulation of transcription by RNA polymerase II
GO:43086; negative regulation of catalytic activity
Cellular component: GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5634; nucleus
Function: GO:3713; transcription coactivator activity
GO:3785; actin monomer binding
GO:3779; actin binding
GO:5515; protein binding
GO:43522; leucine zipper domain binding
GO:4864; protein phosphatase inhibitor activity
Show all GO terms

Homologs of MRTFA in Model Organisms

Danio rerio
mkl1b
Mus musculus
Mkl1
Rattus norvegicus
Mkl1

In other databases

LongevityMap
  • This gene is present as MKL1

External links

OMIM
606078
Ensembl
ENSG00000196588
Entrez Gene
57591
UniGene
654688
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MRTFA
GeneCards
MRTFA