Cell Senescence Entries for MVP

Cell Types
Breast cancer
Cell Lines
MDA-MB-231, MDA-MB-468, SKBR3, T47D, ZR751
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Pasillas et al. (2015) Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Mol Cell Proteomics 14(1)1-14 (PubMed)

MVP Gene Information

HGNC symbol
MVP 
Aliases
LRP; VAULT1 
Common name
major vault protein 
Entrez Id
9961
Description
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].

MVP Ontologies

Gene Ontology
Process: GO:51028; mRNA transport
GO:15031; protein transport
GO:42059; negative regulation of epidermal growth factor receptor signaling pathway
GO:61099; negative regulation of protein tyrosine kinase activity
GO:38127; ERBB signaling pathway
GO:31953; negative regulation of protein autophosphorylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5643; nuclear pore
GO:48471; perinuclear region of cytoplasm
GO:5576; extracellular region
GO:70062; extracellular exosome
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
And 1 more GO terms
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:19901; protein kinase binding
GO:19903; protein phosphatase binding
Show all GO terms

Homologs of MVP in Model Organisms

Danio rerio
mvp
Mus musculus
Mvp
Rattus norvegicus
Mvp

External links

OMIM
605088
Ensembl
ENSG00000013364
Entrez Gene
9961
UniGene
632177
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MVP
GeneCards
MVP