Cell Senescence Entries for MYCN

Cell Types
Marrow myelogenous leukemia
Cell Lines
HEL, K562
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Liu et al. (2018) MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21. Cell Death Dis 8(10)e3126 (PubMed)

MYCN Gene Information

HGNC symbol
MYCN 
Aliases
bHLHe37; MYCNOT; N-myc; NMYC 
Common name
MYCN proto-oncogene, bHLH transcription factor 
Entrez Id
4613
Description
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014].

MYCN Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:10629; negative regulation of gene expression
GO:1903800; positive regulation of production of miRNAs involved in gene silencing by miRNA
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:785; chromatin
Function: GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:19900; kinase binding
Show all GO terms

Homologs of MYCN in Model Organisms

Mus musculus
Mycn
Rattus norvegicus
Mycn

External links

OMIM
164840
Ensembl
ENSG00000134323
Entrez Gene
4613
UniGene
25960
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MYCN
GeneCards
MYCN