Cell Senescence Entries for NDST2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Tordella et al. (2017) SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer. Genes Dev 30(19)2187-2198 (PubMed)

NDST2 Gene Information

HGNC symbol
NDST2 
Aliases
HSST2; NST2 
Common name
N-deacetylase and N-sulfotransferase 2 
Entrez Id
8509
Description
This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009].

NDST2 Ontologies

Gene Ontology
Process: GO:8152; metabolic process
GO:15012; heparan sulfate proteoglycan biosynthetic process
GO:30210; heparin biosynthetic process
GO:6024; glycosaminoglycan biosynthetic process
GO:15014; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO:1901564; organonitrogen compound metabolic process
GO:1901135; carbohydrate derivative metabolic process
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:139; Golgi membrane
Function: GO:16740; transferase activity
GO:16787; hydrolase activity
GO:3824; catalytic activity
GO:8146; sulfotransferase activity
GO:19213; deacetylase activity
GO:15016; [heparan sulfate]-glucosamine N-sulfotransferase activity
GO:50119; N-acetylglucosamine deacetylase activity
Show all GO terms

Homologs of NDST2 in Model Organisms

Caenorhabditis elegans
hst-1
Danio rerio
ndst2
Mus musculus
Ndst2
Rattus norvegicus
Ndst2

External links

OMIM
603268
Ensembl
ENSG00000166507
Entrez Gene
8509
UniGene
654758
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NDST2
GeneCards
NDST2