Cell Senescence Entries for NEK4
- Cell Types
- Foreskin fibroblast
- Cell Lines
- BJ
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Replicative, Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Nguyen et al. (2012) Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Mol Cell Biol 32(19)3963-77 (PubMed)
NEK4 Gene Information
- HGNC symbol
- NEK4
- Aliases
- NRK2; pp12301; STK2
- Common name
- NIMA related kinase 4
- Entrez Id
- 6787
- Description
- The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017].
NEK4 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:6974; cellular response to DNA damage stimulus
GO:2000772; regulation of cellular senescence
GO:278; mitotic cell cycle
GO:45893; positive regulation of transcription, DNA-templated
GO:2001020; regulation of response to DNA damage stimulus
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5929; cilium
GO:42995; cell projection
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:30145; manganese ion binding
Homologs of NEK4 in Model Organisms
External links
- OMIM
- 601959
- Ensembl
- ENSG00000114904
- Entrez Gene
- 6787
- UniGene
- 677083
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- NEK4
- GeneCards
- NEK4