Cell Senescence Entries for NEK4

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Nguyen et al. (2012) Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Mol Cell Biol 32(19)3963-77 (PubMed)

NEK4 Gene Information

HGNC symbol
NEK4 
Aliases
NRK2; pp12301; STK2 
Common name
NIMA related kinase 4 
Entrez Id
6787
Description
The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017].

NEK4 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:6974; cellular response to DNA damage stimulus
GO:2000772; regulation of cellular senescence
GO:278; mitotic cell cycle
GO:45893; positive regulation of transcription, DNA-templated
GO:2001020; regulation of response to DNA damage stimulus
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5929; cilium
GO:42995; cell projection
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:30145; manganese ion binding
Show all GO terms

Homologs of NEK4 in Model Organisms

Danio rerio
nek4
Mus musculus
Nek4
Rattus norvegicus
Nek4

External links

OMIM
601959
Ensembl
ENSG00000114904
Entrez Gene
6787
UniGene
677083
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NEK4
GeneCards
NEK4