Cell Senescence Entries for OTX2

Cell Types
Medulloblastoma
Cell Lines
D283, D341, D425, D458, D556, DAOY, MED8A, UW228-2
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Bunt et al. (2011) Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines. Mol Cancer Res 8(10)1344-57 (PubMed)

OTX2 Gene Information

HGNC symbol
OTX2 
Aliases
 
Common name
orthodenticle homeobox 2 
Entrez Id
5015
Description
This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012].

OTX2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:65003; protein-containing complex assembly
GO:7411; axon guidance
GO:40019; positive regulation of embryonic development
GO:71542; dopaminergic neuron differentiation
GO:30901; midbrain development
GO:8589; regulation of smoothened signaling pathway
GO:30900; forebrain development
And 5 more GO terms
Cellular component: GO:5634; nucleus
GO:32991; protein-containing complex
GO:30426; growth cone
GO:785; chromatin
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:8190; eukaryotic initiation factor 4E binding
Show all GO terms

Homologs of OTX2 in Model Organisms

Danio rerio
otx2
Mus musculus
Otx2

External links

OMIM
600037
Ensembl
ENSG00000165588
Entrez Gene
5015
UniGene
741558
1000 Genomes
1000 Genomes
HPRD
GenAtlas
OTX2
GeneCards
OTX2