Cell Senescence Entries for OXTR

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Liu et al. (2020) A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. Aging (Albany NY) 11(12)4011-4031 (PubMed)

OXTR Gene Information

HGNC symbol
OXTR 
Aliases
OTR 
Common name
oxytocin receptor 
Entrez Id
5021
Description
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008].

OXTR Ontologies

Gene Ontology
Process: GO:7186; G protein-coupled receptor signaling pathway
GO:7165; signal transduction
GO:45907; positive regulation of vasoconstriction
GO:1967; suckling behavior
GO:1975; response to amphetamine
GO:7204; positive regulation of cytosolic calcium ion concentration
GO:7507; heart development
GO:7565; female pregnancy
GO:7613; memory
GO:9410; response to xenobiotic stimulus
GO:10701; positive regulation of norepinephrine secretion
And 32 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
GO:5902; microvillus
GO:5912; adherens junction
GO:16324; apical plasma membrane
Function: GO:4930; G protein-coupled receptor activity
GO:5000; vasopressin receptor activity
GO:4990; oxytocin receptor activity
GO:17046; peptide hormone binding
GO:42277; peptide binding
Show all GO terms

Homologs of OXTR in Model Organisms

Danio rerio
oxtrl
Mus musculus
Oxtr
Rattus norvegicus
Oxtr

External links

OMIM
167055
Ensembl
ENSG00000180914
Entrez Gene
5021
UniGene
2820
1000 Genomes
1000 Genomes
HPRD
GenAtlas
OXTR
GeneCards
OXTR