Cell Senescence Entries for P2RY14
- Cell Types
- Cardiac progenitor cell
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Khalafalla et al. (2018) Empowering human cardiac progenitor cells by P2Y14 nucleotide receptor overexpression. J Physiol 595(23)7135-7148 (PubMed)
P2RY14 Gene Information
- HGNC symbol
- P2RY14
- Aliases
- GPR105; KIAA0001
- Common name
- purinergic receptor P2Y14
- Entrez Id
- 9934
- Description
- The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
P2RY14 Ontologies
- Gene Ontology
-
Process: GO:7186; G protein-coupled receptor signaling pathway
GO:7165; signal transduction
GO:35589; G protein-coupled purinergic nucleotide receptor signaling pathway
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
Show all GO termsFunction: GO:4930; G protein-coupled receptor activity
GO:45028; G protein-coupled purinergic nucleotide receptor activity
GO:45029; G protein-coupled UDP receptor activity
Homologs of P2RY14 in Model Organisms
External links
- OMIM
- 610116
- Ensembl
- ENSG00000174944
- Entrez Gene
- 9934
- UniGene
- 2465
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- P2RY14
- GeneCards
- P2RY14