Cell Senescence Entries for PDCD4

Cell Types
Liver cancer
Cell Lines
Hep G2, Hep3B, Huh7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Guo et al. (2020) PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression. Front Oncol 8(2)661 (PubMed)

PDCD4 Gene Information

HGNC symbol
PDCD4 
Aliases
H731 
Common name
programmed cell death 4 
Entrez Id
27250
Description
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].

PDCD4 Ontologies

Gene Ontology
Process: GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:45786; negative regulation of cell cycle
GO:50729; positive regulation of inflammatory response
GO:71222; cellular response to lipopolysaccharide
GO:1901224; positive regulation of NIK/NF-kappaB signaling
GO:30509; BMP signaling pathway
GO:1905461; positive regulation of vascular associated smooth muscle cell apoptotic process
GO:7569; cell aging
GO:60940; epithelial to mesenchymal transition involved in cardiac fibroblast development
GO:1905064; negative regulation of vascular associated smooth muscle cell differentiation
And 9 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
Function: GO:3723; RNA binding
GO:5515; protein binding
Show all GO terms

Homologs of PDCD4 in Model Organisms

Danio rerio
pdcd4b
Drosophila melanogaster
Pdcd4
Mus musculus
Pdcd4
Rattus norvegicus
Pdcd4

External links

OMIM
608610
Ensembl
ENSG00000150593
Entrez Gene
27250
UniGene
711490
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PDCD4
GeneCards
PDCD4