Cell Senescence Entries for PEBP1
- Cell Types
- Colon cancer, Gastric cancer, Lung cancer, Prostate cancer
- Cell Lines
- A549, HCT116, MKN45, PC-3
- Cancer Cell?
- Yes
- Method
- Knockdown, Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Lee et al. (2014) A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation. Neoplasia 15(7)727-37 (PubMed)
PEBP1 Gene Information
- HGNC symbol
- PEBP1
- Aliases
- HCNP; PBP; PEBP; RKIP
- Common name
- phosphatidylethanolamine binding protein 1
- Entrez Id
- 5037
- Description
- This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015].
PEBP1 Ontologies
- Gene Ontology
-
Process: GO:10951; negative regulation of endopeptidase activity
GO:10466; negative regulation of peptidase activity
GO:43409; negative regulation of MAPK cascade
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
Show all GO termsFunction: GO:3723; RNA binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:5515; protein binding
GO:8289; lipid binding
GO:19899; enzyme binding
GO:4867; serine-type endopeptidase inhibitor activity
GO:30414; peptidase inhibitor activity
GO:19901; protein kinase binding
GO:8429; phosphatidylethanolamine binding
Homologs of PEBP1 in Model Organisms
- Caenorhabditis elegans
- F40A3.3
- Danio rerio
- pebp1
- Drosophila melanogaster
- CG17919
- Mus musculus
- Pebp1
- Rattus norvegicus
- Pbp2
- Saccharomyces cerevisiae
- TFS1
External links
- OMIM
- 604591
- Ensembl
- ENSG00000089220
- Entrez Gene
- 5037
- UniGene
- 433863
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PEBP1
- GeneCards
- PEBP1