Cell Senescence Entries for PLK1

Cell Types

Dermal fibroblast, Umbilical vein endothelial

Cell Lines

HUVEC, Primary cell

Cancer Cell?

No

Method

Knockdown, Overexpression

Type of senescence

Replicative

Senescence Effect

Inhibits

Primary Reference

Kim et al. (2013) Downregulation of Polo-like kinase 1 induces cellular senescence in human primary cells through a p53-dependent pathway. J Gerontol A Biol Sci Med Sci 68(10)1145-56 (PubMed)

PLK1 Gene Information

HGNC symbol

PLK1 

Aliases

PLK 

Common name

polo like kinase 1 

Entrez Id

5347

Description

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015].

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PLK1 Ontologies

Gene Ontology

Process:

GO:6468; protein phosphorylation GO:7049; cell cycle GO:16310; phosphorylation GO:43066; negative regulation of apoptotic process GO:16567; protein ubiquitination GO:51301; cell division GO:122; negative regulation of transcription by RNA polymerase II GO:18105; peptidyl-serine phosphorylation GO:132; establishment of mitotic spindle orientation GO:31648; protein destabilization GO:1578; microtubule bundle formation

And 36 more GO terms

Cellular component:	GO:5634; nucleus GO:5737; cytoplasm GO:5856; cytoskeleton GO:5694; chromosome GO:775; chromosome, centromeric region GO:5815; microtubule organizing center GO:5819; spindle GO:776; kinetochore GO:30496; midbody GO:5813; centrosome GO:5654; nucleoplasm
	And 13 more GO terms

Function:	GO:166; nucleotide binding GO:4672; protein kinase activity GO:5524; ATP binding GO:5515; protein binding GO:4674; protein serine/threonine kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:16301; kinase activity GO:16740; transferase activity GO:106310; protein serine kinase activity GO:8017; microtubule binding GO:42802; identical protein binding
	And 4 more GO terms

Show all GO terms

Homologs of PLK1 in Model Organisms

Caenorhabditis elegans

plk-2

Danio rerio

plk1

Drosophila melanogaster

polo

Mus musculus

Plk1

Rattus norvegicus

Plk1

In other databases

CellAge gene expression

• This gene is present as PLK1

External links

OMIM

602098

Ensembl

ENSG00000166851

Entrez Gene

5347

UniGene

592049

1000 Genomes

1000 Genomes

HPRD

GenAtlas

PLK1

GeneCards

PLK1