Cell Senescence Entries for POU5F1

Cell Types
Mesenchymal stromal
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Jaganathan et al. (2013) Human mesenchymal stromal cells senesce with exogenous OCT4. Cytotherapy 14(9)1054-63 (PubMed)

POU5F1 Gene Information

HGNC symbol
POU5F1 
Aliases
MGC22487; OCT3; Oct4; OTF3 
Common name
POU class 5 homeobox 1 
Entrez Id
5460
Description
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013].

POU5F1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:10468; regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:9653; anatomical structure morphogenesis
GO:9611; response to wounding
GO:1824; blastocyst development
GO:1902894; negative regulation of pri-miRNA transcription by RNA polymerase II
GO:35019; somatic stem cell population maintenance
GO:1714; endodermal cell fate specification
And 12 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:785; chromatin
GO:5667; transcription regulator complex
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:976; transcription cis-regulatory region binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:31625; ubiquitin protein ligase binding
And 5 more GO terms
Show all GO terms

Homologs of POU5F1 in Model Organisms

No homologs found

External links

OMIM
164177
Ensembl
ENSG00000204531
Entrez Gene
5460
UniGene
249184
1000 Genomes
1000 Genomes
HPRD
GenAtlas
POU5F1
GeneCards
POU5F1