Cell Senescence Entries for PRKAA2

Cell Types
Lung fibroblast, Umbilical vein endothelial
Cell Lines
HUVEC, MRC-5
Cancer Cell?
No
Method
Mutation
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Han et al. (2017) AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation. Aging Cell 15(3)416-27 (PubMed)

PRKAA2 Gene Information

HGNC symbol
PRKAA2 
Aliases
AMPK; AMPKa2; PRKAA 
Common name
protein kinase AMP-activated catalytic subunit alpha 2 
Entrez Id
5563
Description
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].

PRKAA2 Ontologies

Gene Ontology
Process: GO:10629; negative regulation of gene expression
GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:6325; chromatin organization
GO:6629; lipid metabolic process
GO:6631; fatty acid metabolic process
GO:6633; fatty acid biosynthetic process
GO:6694; steroid biosynthetic process
GO:6695; cholesterol biosynthetic process
GO:8202; steroid metabolic process
And 35 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:43025; neuronal cell body
GO:30424; axon
GO:30425; dendrite
GO:31588; nucleotide-activated protein kinase complex
GO:10494; cytoplasmic stress granule
And 1 more GO terms
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4679; AMP-activated protein kinase activity
And 5 more GO terms
Show all GO terms

Homologs of PRKAA2 in Model Organisms

No homologs found

External links

OMIM
600497
Ensembl
ENSG00000162409
Entrez Gene
5563
UniGene
437039
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKAA2
GeneCards
PRKAA2