Cell Senescence Entries for PRKCD

Cell Types
Lung fibroblast
Cell Lines
TIG-1
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Katakura et al. (2009) Protein kinase C delta plays a key role in cellular senescence programs of human normal diploid cells. J Biochem 146(1)87-93 (PubMed)

PRKCD Gene Information

HGNC symbol
PRKCD 
Aliases
 
Common name
protein kinase C delta 
Entrez Id
5580
Description
The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017].

PRKCD Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:18108; peptidyl-tyrosine phosphorylation
GO:2000303; regulation of ceramide biosynthetic process
GO:80090; regulation of primary metabolic process
GO:18105; peptidyl-serine phosphorylation
GO:42742; defense response to bacterium
GO:35556; intracellular signal transduction
GO:50821; protein stabilization
And 39 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:12505; endomembrane system
GO:48471; perinuclear region of cytoplasm
GO:5576; extracellular region
GO:5654; nucleoplasm
And 6 more GO terms
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
And 10 more GO terms
Show all GO terms

Homologs of PRKCD in Model Organisms

Danio rerio
BX005175.1
Mus musculus
Prkcd
Rattus norvegicus
Prkcd
Schizosaccharomyces pombe
pck1

In other databases

GenAge human genes
  • This gene is present as PRKCD

External links

OMIM
176977
Ensembl
ENSG00000163932
Entrez Gene
5580
UniGene
155342
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKCD
GeneCards
PRKCD