Cell Senescence Entries for PRKCH

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Zurgil et al. (2015) PKCĪ· promotes senescence induced by oxidative stress and chemotherapy. Cell Death Dis 5(2)e1531 (PubMed)

PRKCH Gene Information

HGNC symbol
PRKCH 
Aliases
PKC-L; PKCL; PRKCL 
Common name
protein kinase C eta 
Entrez Id
5583
Description
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015].

PRKCH Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:30154; cell differentiation
GO:35556; intracellular signal transduction
GO:18105; peptidyl-serine phosphorylation
GO:2000810; regulation of bicellular tight junction assembly
GO:7165; signal transduction
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:34351; negative regulation of glial cell apoptotic process
GO:10744; positive regulation of macrophage derived foam cell differentiation
GO:45618; positive regulation of keratinocyte differentiation
And 4 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5886; plasma membrane
GO:5829; cytosol
GO:70062; extracellular exosome
Function: GO:4672; protein kinase activity
GO:5524; ATP binding
GO:4674; protein serine/threonine kinase activity
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4697; protein kinase C activity
And 3 more GO terms
Show all GO terms

Homologs of PRKCH in Model Organisms

Caenorhabditis elegans
pkc-1
Danio rerio
prkcha
Drosophila melanogaster
Pkc98E
Mus musculus
Prkch
Rattus norvegicus
Prkch

External links

OMIM
605437
Ensembl
ENSG00000027075
Entrez Gene
5583
UniGene
662187
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKCH
GeneCards
PRKCH