Cell Senescence Entries for PRKD2

Cell Types
Glioblastoma, Glioma
Cell Lines
A172, GBM2, Gli25, GM133, T98G, U251, U87MG
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Bernhart et al. (2015) Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways. Neuro Oncol 16(7)933-45 (PubMed)

PRKD2 Gene Information

HGNC symbol
PRKD2 
Aliases
DKFZP586E0820; HSPC187; PKD2 
Common name
protein kinase D2 
Entrez Id
25865
Description
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

PRKD2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:7155; cell adhesion
GO:2376; immune system process
GO:18105; peptidyl-serine phosphorylation
GO:2250; adaptive immune response
GO:1525; angiogenesis
GO:50862; positive regulation of T cell receptor signaling pathway
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:45944; positive regulation of transcription by RNA polymerase II
And 28 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4697; protein kinase C activity
And 3 more GO terms
Show all GO terms

Homologs of PRKD2 in Model Organisms

Caenorhabditis elegans
dkf-2
Drosophila melanogaster
PKD
Mus musculus
Prkd2
Rattus norvegicus
Prkd2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as dkf-2

External links

OMIM
607074
Ensembl
ENSG00000105287
Entrez Gene
25865
UniGene
466987
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKD2
GeneCards
PRKD2