Cell Senescence Entries for PSMA5

Cell Types
Colorectal cancer, Melanoma
Cell Lines
A375P, HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

PSMA5 Gene Information

HGNC symbol
PSMA5 
Aliases
ZETA 
Common name
proteasome 20S subunit alpha 5 
Entrez Id
5686
Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010].

PSMA5 Ontologies

Gene Ontology
Process: GO:6511; ubiquitin-dependent protein catabolic process
GO:16579; protein deubiquitination
GO:43488; regulation of mRNA stability
GO:43687; post-translational protein modification
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:165; MAPK cascade
GO:2223; stimulatory C-type lectin receptor signaling pathway
GO:2479; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:6521; regulation of cellular amino acid metabolic process
GO:10972; negative regulation of G2/M transition of mitotic cell cycle
And 17 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:502; proteasome complex
GO:5839; proteasome core complex
GO:19773; proteasome core complex, alpha-subunit complex
GO:5576; extracellular region
GO:5654; nucleoplasm
GO:70062; extracellular exosome
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
And 1 more GO terms
Function: GO:5515; protein binding
Show all GO terms

Homologs of PSMA5 in Model Organisms

Caenorhabditis elegans
pas-5
Danio rerio
psma5
Drosophila melanogaster
Prosalpha5
Mus musculus
Psma5
Rattus norvegicus
Psma5
Saccharomyces cerevisiae
PUP2
Schizosaccharomyces pombe
pup2

External links

OMIM
176844
Ensembl
ENSG00000143106
Entrez Gene
5686
UniGene
485246
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PSMA5
GeneCards
PSMA5