Cell Senescence Entries for RAN

Cell Types
Lung fibroblast
Cell Lines
TIG-1
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Nagai et al. (2013) Downregulation of the small GTPase ras-related nuclear protein accelerates cellular ageing. Biochim Biophys Acta 1830(3)2813-9 (PubMed)

RAN Gene Information

HGNC symbol
RAN 
Aliases
ARA24; Gsp1; TC4 
Common name
RAN, member RAS oncogene family 
Entrez Id
5901
Description
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008].

RAN Ontologies

Gene Ontology
Process: GO:15031; protein transport
GO:6913; nucleocytoplasmic transport
GO:7049; cell cycle
GO:51301; cell division
GO:6259; DNA metabolic process
GO:54; ribosomal subunit export from nucleus
GO:6606; protein import into nucleus
GO:7052; mitotic spindle organization
GO:46039; GTP metabolic process
GO:278; mitotic cell cycle
GO:32092; positive regulation of protein binding
And 10 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5814; centriole
GO:5635; nuclear envelope
GO:5829; cytosol
GO:785; chromatin
GO:5730; nucleolus
GO:5643; nuclear pore
And 6 more GO terms
Function: GO:166; nucleotide binding
GO:3924; GTPase activity
GO:5525; GTP binding
GO:5515; protein binding
GO:3723; RNA binding
GO:46872; metal ion binding
GO:287; magnesium ion binding
GO:3682; chromatin binding
GO:45296; cadherin binding
GO:19003; GDP binding
GO:46982; protein heterodimerization activity
And 3 more GO terms
Show all GO terms

Homologs of RAN in Model Organisms

Caenorhabditis elegans
ran-1
Danio rerio
ran
Drosophila melanogaster
ran
Mus musculus
Ran
Rattus norvegicus
Ran
Saccharomyces cerevisiae
GSP2
Schizosaccharomyces pombe
spi1

External links

OMIM
601179
Ensembl
ENSG00000132341
Entrez Gene
5901
UniGene
10842
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RAN
GeneCards
RAN