Cell Senescence Entries for RASSF1

Cell Types
Lung cancer
Cell Lines
A549, NCI-H1299
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Induces
Primary Reference
Thaler et al. (2009) RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt. Cancer Res 69(5)1748-57 (PubMed)

RASSF1 Gene Information

HGNC symbol
RASSF1 
Aliases
123F2; NORE2A; RDA32; REH3P21 
Common name
Ras association domain family member 1 
Entrez Id
11186
Description
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011].

RASSF1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:7165; signal transduction
GO:70507; regulation of microtubule cytoskeleton organization
GO:7265; Ras protein signal transduction
GO:6974; cellular response to DNA damage stimulus
GO:51726; regulation of cell cycle
GO:31398; positive regulation of protein ubiquitination
GO:50821; protein stabilization
GO:1902806; regulation of cell cycle G1/S phase transition
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5874; microtubule
GO:5815; microtubule organizing center
GO:5819; spindle
GO:922; spindle pole
GO:15630; microtubule cytoskeleton
Function: GO:46872; metal ion binding
GO:8270; zinc ion binding
GO:5515; protein binding
GO:47485; protein N-terminus binding
GO:42802; identical protein binding
Show all GO terms

Homologs of RASSF1 in Model Organisms

Danio rerio
rassf1
Mus musculus
Rassf1
Rattus norvegicus
Rassf1

External links

OMIM
605082
Ensembl
ENSG00000068028
Entrez Gene
11186
UniGene
476270
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RASSF1
GeneCards
RASSF1