Cell Senescence Entries for RBL2
- Cell Types
- Breast cancer, Colon cancer, Glioblastoma, Osteosarcoma
- Cell Lines
- A172, HCT116, MCF-7, U2OS, U87
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Primary Reference
- Helmbold et al. (2009) Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence. Oncogene 28(39)3456-67 (PubMed)
RBL2 Gene Information
- HGNC symbol
- RBL2
- Aliases
- p130; Rb2
- Common name
- RB transcriptional corepressor like 2
- Entrez Id
- 5934
- Description
RBL2 Ontologies
- Gene Ontology
-
Process: GO:6357; regulation of transcription by RNA polymerase II
GO:51726; regulation of cell cycle
GO:51302; regulation of cell division
GO:7049; cell cycle
GO:6325; chromatin organization
GO:30154; cell differentiation
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:10629; negative regulation of gene expression
GO:43550; regulation of lipid kinase activity
Cellular component: GO:5667; transcription regulator complex
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:5694; chromosome
GO:70062; extracellular exosome
GO:785; chromatin
Show all GO termsFunction: GO:3677; DNA binding
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1990841; promoter-specific chromatin binding
Homologs of RBL2 in Model Organisms
External links
- OMIM
- 180203
- Ensembl
- ENSG00000103479
- Entrez Gene
- 5934
- UniGene
- 513609
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RBL2
- GeneCards
- RBL2