The RBP2 gene and its putative association with human ageing

Cell Senescence Entries for RBP2

Cell Types: Cervical cancer, Gastric cancer
Cell Lines: AGS, BGC-823, HeLa, HGC-27, KATO-III, SiHa
Cancer Cell?: Yes
Method: Knockout
Type of senescence: Unclear
Senescence Effect: Inhibits
Primary Reference: Zeng et al. (2010) The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells. Gastroenterology 138(3)981-92 (PubMed)

HGNC symbol: RBP2
Aliases: CRABP-II; CRBP2; CRBPII; RBPC2
Common name: retinol binding protein 2
Entrez Id: 5948
Description: This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015].

Gene Ontology

Process:

GO:15908; fatty acid transport
GO:8544; epidermis development
GO:6776; vitamin A metabolic process

Cellular component:

GO:5737; cytoplasm
GO:5634; nucleus
GO:5829; cytosol

Function:

GO:8289; lipid binding
GO:5504; fatty acid binding
GO:16918; retinal binding
GO:19841; retinol binding
GO:5501; retinoid binding

Show all GO terms